Most bone metastases are lytic, and a distinct periosteal reaction is less common than in primary bone malignancies (61). It stands for, F -Fibrous Dysplasia E -Eosinophilic granuloma and Enchondroma G -Giant cell tumour N -Nonossifying fibroma O -Osteoblastoma M-Metastases and Myeloma A -Aneurysmal bone cyst S -Solitary bone cyst H -Hyperparathyroidism (brown tumours) I -Infection … Tumors that result from these cells entering the ... Often, bone metastases have both lytic and blastic features. How- ever, primary bone tumours, osteomyelitis, or Paget’s Skeletal metastases are found in 30%-70% of patients with malignancy at autopsy. We have attempted to describe the most characteristic features of each of these tumors. FOG MACHINES. Lytic Bone Lesions Mnemonic: FOG MACHINES. 12 Osteoclasts are large, multinucleated cells with a specialized cell membrane (the “ruffled border”) that resorb bone, and osteoblasts are smaller, mononucleated cells that form new bone. 1. FOG MACHINES-F: fibrous dysplasia (FD) or fibrous cortical defect (FCD) O: osteoblastoma G: giant cell tumor (GCT) M: metastasis(es)/myeloma A: aneurysmal bone cyst (ABC) C: chondroblastoma or chondromyxoid fibroma H: hyperparathyroidism (brown tumor) I: infection (osteomyelitis) N: non-ossifying fibroma (NOF) E: enchondroma or eosinophilic granuloma (EG) S: simple (unicameral) bone … Bone Metastasis Cancer cells that break off from a primary tumor and enter the bloodstream or lymph vessels can reach nearly all tissues of the body. Post navigation. Bone metastasis has a predilection for hematopoietic bone marrow such as spine, pelvis, rib, cranium and proximal long bones. This is an impending fracture according to Harrington’s criteria as well. 13 These cells produce lytic … Unlike hematological malignancies that originate in the blood and form non-solid tumors, bone metastases generally arise from epithelial … Mnemonics for lytic bone lesions include: FEGNOMASHIC. Dr.Vineel Bezawada M.S (orthopaedics) 2. History: 60 year old male with lung cancer. This patient had metastatic lung cancer to the bones. Bones are a common place for these cancer cells to settle and start growing. Bone metastases, or osseous metastatic disease, is a category of cancer metastases that results from primary tumor invasion to bone.Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing's sarcoma are rare. It is necessary to prescribe the mechanical properties of tumor tissue when modeling the metastatically involved skeleton for clarifying the mechanisms of fracture. 3 Renal, breast, thyroid, and lung carcinoma are the common causes of lytic bone metastases. Bone metastases can be classified as lytic, blastic, or mixed depending on the activity of tumor-stimulated host osteoclasts and osteoblasts. For simplicity, a widely used mnemonic for lytic bone lesions is extremely helpful: FEGNOMASHIC. They are by no means exhaustive lists, but are a good start for remembering a differential for a lytic bone lesion. Osteolytic lesions of Bone. Specimens of human lytic tumor were tested under a confined com … FEGNOMASCHIC is commonly used mnemonic for the differentiation of benign lytic bone lesions. Example: A lytic metastasis in the proximal diaphysis of right femur which encompasses half of the diameter of bone producing severe limb pain at rest would score: 3 (lytic) + 2 (lower limb) + 2 (1/2 diameter) + 3 (functional pain) = 10. They are anagrams of each other and therefore include the same components. Metastases located in vertebral bodies do not affect the intervertebral discs, in contrast osteomyelitis (2). This study provides mechanical property data for lytic bone metastases. Lytic metastases (70% of cases) are more common than blastic metastases (15%) or mixed lesions (10%) . SOLITARY LYTIC BONE LESION. Differential Diagnosis (Mnemonic = FOGMACHINES) F = Fibrous Dysplasia O = Osteoblastoma G = Giant Cell Tumour M = Metastasis / Myeloma A = Aneurysmal Bone Cyst C = Chondroblastoma H = Hyperparathyroidism(brown tumours)/ Hemangioma I = Infection N = Non-ossifying Fibroma E = Eosinophilic Granuloma / … Bone metastases are classified as either blastic or lytic: Lytic bone metastases occur in the following cancers: renal, lung, breast, thyroid, melanoma, chordoma, paraganglioma, GI tract, urothelial, ovarian, melanoma, chordoma, and paraganglioma. When you see lytic bone lesion think of FOGMACHINE.
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